Heterogeneities in stem cell mechanics during division and exit from pluripotency (360G-Wellcome-201334_Z_16_Z)
Embryonic stem cells are pluripotent cells that can give rise to the three germ layers. Evidence indicates they can maintain pluripotency whilst giving rise to progenitor cells for all the embryo cells, suggesting that they are capable of asymmetric division. However, the cell biology of embryonic stem cell division is poorly understood. Interestingly, embryonic stem cells have mechanical properties very different from their differentiated counterparts, and their fate is strongly influenced by the mechanical properties of the substrate, suggesting that stem cell division might be asymmetric with respect to daughter cell mechanics. We propose to explore the geometry, mechanics and physical control by the environment of stem cell division using mouse embryonic stem cells as a model. We will follow cell division and the fate of the daughter cells at the single cell level and in colonies. Altogether, this project will broaden our understanding of the molecular and biophysical control of embryonic stem cell division, a process key to stem cell homeostasis and embryonic development, and will clarify how cell shape and mechanics influence embryonic stem cell fate.
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Grant Details
| Amount Awarded | 250000 |
| Applicant Surname | Chaigne |
| Approval Committee | Basic Science Interview Committee |
| Award Date | 2016-04-19T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
| Internal ID | 201334/Z/16/Z |
| Lead Applicant | Dr Agathe Chaigne |
| Partnership Value | 250000 |
| Planned Dates: End Date | 2021-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-09-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Mark Marsh |