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Combined liposomal delivery of small molecule and oligonucleotide therapeutics (360G-Wellcome-202339_Z_16_Z)

Liposomal delivery of therapeutic agents, and/or imaging agents, is an important and rapidly emerging area which will have considerable impact on many disease areas including respiratory diseases, vaccine delivery and cancer. These liposome-based formulations are increasingly important for delivery and imaging of small molecule therapeutics, and for the delivery of plasmid DNA encoding for imaging agents or toxic genes, as they offer the benefits of cell-selective delivery with minimal off-target effects. However, to date it has not been possible to formulate both small molecule therapeutics and plasmid DNA in the same nanoparticle delivery system. The aim of this research is to develop multifunctional nanoparticles for liposomal delivery of both a small molecule therapeutic and plasmid DNA. This will have the advantage of delivering two different therapies to the same diseased cell, ensuring more rapid therapeutic effect and minimising the development of resistance to each individual therapeutic intervention.

£2,000

01 Apr 2016

Grant details
Amount Awarded 2000
Applicant Surname Draganov
Approval Committee Internal Decision Panel for C&S
Award Date 2016-04-01T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Vacation Scholarships
Internal ID 202339/Z/16/Z
Lead Applicant Mr Simeon Draganov
Planned Dates: End Date 2016-08-19T00:00:00+00:00
Planned Dates: Start Date 2016-06-20T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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