Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

The Involvement of Ventral Hippocampal Circuitry in Social Interaction (360G-Wellcome-202480_Z_16_Z)

<p>The research project represents an initial investigation into the role of the diverse components of the ventral hippocampal circuitry in the context of social interaction.</p> <p>&nbsp;</p> <p>The aim is to explore a potential correlation between complex behavioural patterns observed during social interaction tasks and degree of activation of ventral hippocampal neurons.</p> <p>&nbsp;</p> <p>Behavioural assessment will only be carried out on single housed male mice to avoid sex-specific differences. During my experiments I will compare two contexts. First, as a control, mice will be placed in a test chamber with a novel object. Second, social interaction will be tested by introducing a juvenile male. The behavioural patterns generated will be scored and compared both qualitatively and quantitatively.</p> <p>&nbsp;</p> <p>After 90 minutes, the degree of activation&nbsp;of distinct ventral hippocampal areas (CA1, CA2, CA3, Dentate Gyrus and Subiculum) will be tested in each of these groups of mice using expression of the immediate-early gene <em>c-fos</em>&nbsp;(which is correlated to neuronal activation), by optimising immunohistochemical detection in the lab.&nbsp;</p> <p>&nbsp;</p> <p>I will then aim to establish the involvement of the ventral hippocampus in social interaction by&nbsp;using&nbsp;fluorescent microscopy analysis, followed by appropriate statistical testing between the control and social groups.&nbsp;</p>


01 Apr 2016

Grant details
Amount Awarded 2000
Applicant Surname Menichini
Approval Committee Internal Decision Panel for C&S
Award Date 2016-04-01T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Vacation Scholarships
Internal ID 202480/Z/16/Z
Lead Applicant Miss Elena Menichini
Planned Dates: End Date 2016-09-25T00:00:00+00:00
Planned Dates: Start Date 2016-07-25T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Additional data added by GrantNav