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The Involvement of Ventral Hippocampal Circuitry in Social Interaction (360G-Wellcome-202480_Z_16_Z)

<p>The research project represents an initial investigation into the role of the diverse components of the ventral hippocampal circuitry in the context of social interaction.</p> <p>&nbsp;</p> <p>The aim is to explore a potential correlation between complex behavioural patterns observed during social interaction tasks and degree of activation of ventral hippocampal neurons.</p> <p>&nbsp;</p> <p>Behavioural assessment will only be carried out on single housed male mice to avoid sex-specific differences. During my experiments I will compare two contexts. First, as a control, mice will be placed in a test chamber with a novel object. Second, social interaction will be tested by introducing a juvenile male. The behavioural patterns generated will be scored and compared both qualitatively and quantitatively.</p> <p>&nbsp;</p> <p>After 90 minutes, the degree of activation&nbsp;of distinct ventral hippocampal areas (CA1, CA2, CA3, Dentate Gyrus and Subiculum) will be tested in each of these groups of mice using expression of the immediate-early gene <em>c-fos</em>&nbsp;(which is correlated to neuronal activation), by optimising immunohistochemical detection in the lab.&nbsp;</p> <p>&nbsp;</p> <p>I will then aim to establish the involvement of the ventral hippocampus in social interaction by&nbsp;using&nbsp;fluorescent microscopy analysis, followed by appropriate statistical testing between the control and social groups.&nbsp;</p>

£2,000

01 Apr 2016

Grant details
Amount Awarded 2000
Applicant Surname Menichini
Approval Committee Internal Decision Panel for C&S
Award Date 2016-04-01T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Vacation Scholarships
Internal ID 202480/Z/16/Z
Lead Applicant Miss Elena Menichini
Planned Dates: End Date 2016-09-25T00:00:00+00:00
Planned Dates: Start Date 2016-07-25T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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