Harnessing Diversity Generating Retroelements (DGRs) for in vivo evolution (360G-Wellcome-202593_Z_16_Z)
The goal of the project is to express the reverse transcriptase (RT), central to the Bordertella phage BPP-1 diversity generating retroelement (DGR), and test it for synthetic nucleic acid (XNA) synthesis as well as reverse transcription. In addition, I will focus on cloning the BPP-1 DGR elements into E. coli, creating a circuit where DGR function can activate a selectable marker (e.g. kanR). I will try and demonstrate that the BPP-1 DGR is active in E. coli and can be used as a tool for in vivo directed evolution.
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Grant Details
| Amount Awarded | 2000 |
| Applicant Surname | Handal Marquez |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-04-01T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 202593/Z/16/Z |
| Lead Applicant | Miss Paola Handal Marquez |
| Partnership Value | 2000 |
| Planned Dates: End Date | 2016-08-26T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-06-27T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |