Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage (360G-Wellcome-203699_Z_16_Z)

BackgroundStroke due to spontaneous intracerebral haemorrhage (ICH) annually affects ~3.4 million adults worldwide.Approximately 85% of ICHs are thought to be caused by cerebral small vessel diseases (SVDs), such asarteriolosclerosis and cerebral amyloid angiopathy (CAA), which are often studied individually rather than incombination. While SVDs are definitively diagnosed at autopsy, advanced neuroimaging can demonstratebiomarkers and features indicating SVDs, and could help identify their contributions to ICH occurrence,severity and outcome ante mortem.HypothesisMultiple imaging biomarkers of SVDs on one or more imaging modalities will be superior to singlebiomarkers for detecting and distinguishing SVDs underlying ICH, and determining outcome.Key methods/goals1. I will use CT and MR imaging from an on-going inception cohort study of ICH to assess imagingbiomarkers of SVDs, and correlate these with clinical, genetic and pathological findings.2. I will investigate the feasibility and utility of identifying CAA using flutemetamol, in vivo with MRpositronemission tomography, and ex vivo with autoradiography/autofluorescence studies on braintissue.3. I will compare the association between MR-PET imaging phenotype in different types of ICH (lobarand deep).