Epstein Barr Virus: Paving the way for a vaccine using epidemiological and mathematical modelling approaches (360G-Wellcome-204419_Z_16_Z)

£88,097

Epstein Barr Virus (EBV), a Lymphocryptovirus, permanently infects > 90% of humans. EBV causes > 90% of glandular fever, and is linked to 1% of global cancers. Why only a small fraction of infected individuals get cancer is poorly understood. No anti-EBV vaccines are currently licensed, although several candidates are in pre-clinical development. Lymphocryptoviruses have evolved with humans for many millennia. Our immune systems are likely to be well-adapted to EBV and vice versa. The impact of EBV infection through the human life-course is not known, nor is that of remaining permanently EBV-negative. As vaccines become available such questions will become increasingly important. Information derived from large cohorts and mathematical models of transmission will be critical before vaccines can be adopted. Prior to extensive vaccine investment a feasibility and scoping exercise of currently available data and resources is required. Our goals are: 1) Using pre-existing datasets, pilot assembly of a cohort of EBV-seronegative individuals for a life-course study; 2) Undertake systematic reviews to determine the strength of available evidence for different risk factors for EBV infection and EBV-associated cancers in different settings; 3) Develop a preliminary transmission dynamic model for vaccination, and identify knowledge gaps for a full model.

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Grant Details

Amount Awarded 88097
Applicant Surname Stagg
Approval Committee Science Seeds Advisory Panel
Award Date 2016-08-15T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Seed Award in Science
Internal ID 204419/Z/16/Z
Lead Applicant Dr Helen Stagg
Partnership Value 88097
Planned Dates: End Date 2018-06-01T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London