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Co-evolution of tumour mutational and CD4 T-cell differentiation landscapes (360G-Wellcome-211166_Z_18_Z)

Lung cancer is the second most commonly diagnosed cancer in the UK and the greatest cause of cancer-related death. A type of this disease called non-small cell lung cancer (NSCLC) accounts for the majority (85%) of cases. T-lymphocyte cells (T-cells) of the immune system patrol the body and can recognise and destroy cancer cells by recognising mutated proteins (neoantigens) on them. Despite this, the majority of patients with advanced lung cancer die of the disease, indicating the ineffective function of the immune system. In particular, little is known about the role of a particular group of immune cells called T-helper cells that are thought to be important. In chronic infections where T-cells are constantly exposed to their targets, they become less responsive as younger cells are driven to turn into later ones more rapidly. As younger cells are lost, the body's ability to fight the infection reduces. In cancer, it is possible that mutations drive a similar problem. Using lung cancer specimens from patients on a clinical trial and animal models of cancer, we propose to study the question of whether and how mutations can paralyse the ability of T-helper cells to fight the disease.

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30 Sep 2018

Grant details
Amount Awarded 0
Applicant Surname Ghorani
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 211166/Z/18/Z
Lead Applicant Dr Ehsan Ghorani
Planned Dates: End Date 2020-09-03T00:00:00+00:00
Planned Dates: Start Date 2017-09-04T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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