Vesicle dynamics and synaptic computation. (360G-Wellcome-064413_Z_01_A)
This proposal aims to build a quantitative understanding of synaptic function by providing direct links between molecular mechanisms and synaptic computation. We will focus mainly on the cerebellar mossy fibre-granule cell synapse, a model system that is well suited for this purpose. A core aim is todevelop a high resolution optical assay of vesicular release by applying new confocal methods to acute slices from transgenic mice expressing synaptopHluorin. This and recent advances in patching presynaptic terminals will be used to characterize, systematically, vesicle supply, Ca2+-dependenceof release and vesicle recycling. A kinetic model of the vesicle cycle will bedeveloped to elucidate the key determinants of synaptic function. The molecular determinants of specific presynaptic processes will be identified bycomparing model predictions with the behaviour of synapses when protein interactions are altered in transgenic mice or with peptides. Postsynaptically, AMPA receptor function will be examined with localized glutamate uncaging. Key subsynaptic processes will be linked to function by
Where is this data from?
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Grant Details
| Region | London |
| Award Date | 2006-06-01T00:00:00+00:00 |
| Sponsor(s) | Prof John Carroll |
| Internal ID | 064413/Z/01/A |
| Planned Dates: End Date | 2011-08-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2006-09-01T00:00:00+00:00 |
| Amount Awarded | 1280783 |
| Financial Year | 2005/06 |
| Lead Applicant | Prof Robin Angus Silver |
| Grant Programme: Title | Senior Research Fellowship Basic Renewal |
| Applicant Surname | Silver |
| Approval Committee | Basic Science Interview Committee |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | London |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 1280783 |