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Vesicle dynamics and synaptic computation. (360G-Wellcome-064413_Z_01_A)

This proposal aims to build a quantitative understanding of synaptic function by providing direct links between molecular mechanisms and synaptic computation. We will focus mainly on the cerebellar mossy fibre-granule cell synapse, a model system that is well suited for this purpose. A core aim is todevelop a high resolution optical assay of vesicular release by applying new confocal methods to acute slices from transgenic mice expressing synaptopHluorin. This and recent advances in patching presynaptic terminals will be used to characterize, systematically, vesicle supply, Ca2+-dependenceof release and vesicle recycling. A kinetic model of the vesicle cycle will bedeveloped to elucidate the key determinants of synaptic function. The molecular determinants of specific presynaptic processes will be identified bycomparing model predictions with the behaviour of synapses when protein interactions are altered in transgenic mice or with peptides. Postsynaptically, AMPA receptor function will be examined with localized glutamate uncaging. Key subsynaptic processes will be linked to function by

£1,280,783

01 Jun 2006

Grant details
Amount Awarded 1280783
Applicant Surname Silver
Approval Committee Basic Science Interview Committee
Award Date 2006-06-01T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Senior Research Fellowship Basic Renewal
Internal ID 064413/Z/01/A
Lead Applicant Prof Robin Angus Silver
Planned Dates: End Date 2011-08-31T00:00:00+00:00
Planned Dates: Start Date 2006-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof John Carroll
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