The role of glucocorticoid receptor in body composition. (360G-Wellcome-072877_Z_03_C)
The role of glucocorticoid receptor in body composition 1. To generate a line of GR+/- mice from an existing embryonic stem (ES) cell line and phenotype mice with respect to tissue glucocorticoid sensitivity, HPA axis regulation, susceptibility to dietary-induced obesity (DIO) and body fat distribution. 2. To determine key parameters of glucocorticoid action (GR and 11ßHSD1) in metabolically important tissues (liver, adipose, brain) and their role in body fat distribution in POMC-deficient mice, an established model of HPA hypoactivity which also show hyperphagic obesity on a high fat diet. 3. To determine if GR heterozygosity affects the degree and distribution of obesity induced by HF feeding in POMC+/- mice.
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Grant Details
| Amount Awarded | 39144 |
| Applicant Surname | Michailidou |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2005-12-14T00:00:00+00:00 |
| Financial Year | 2005/06 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 072877/Z/03/C |
| Lead Applicant | Dr Zoi Michailidou |
| Partnership Value | 39144 |
| Planned Dates: End Date | 2007-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2004-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Richard Maizels |