Heart physiome. (360G-Wellcome-073068_Z_03_A)
1. An integration of large-scale computer modelling with experimental studies is necessary to understand the mechanisms that underlie re-entrant arrhythmia and fibrillation in the heart. The project brings together Bioengineers from the University of Auckland, NZ and the experimental biologists from Oxford. There are three linked goals. To understand how cardiac arrhythmias at the whole heart level can occur as a result of ion channel mutations, ischaemia and drug toxicity. To demonstrate the use of integrative multi-scale modelling (at the levels of proteins, biochemical pathways, cells, tissues and whole organs) as 'proof of concept' for further such 'physiome' projects. To provide electro-cardiologists with web-accessible software tools and databases for use in generating new hypotheses and interpreting complex experimental data.
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Grant Details
| Amount Awarded | 89747 |
| Applicant Surname | Paterson |
| Approval Committee | Physiological Sciences Funding Committee |
| Award Date | 2006-11-09T00:00:00+00:00 |
| Financial Year | 2006/07 |
| Grant Programme: Title | Programme Grant |
| Internal ID | 073068/Z/03/A |
| Lead Applicant | Prof David Paterson |
| Other Applicant(s) | Prof Denis Noble, Prof Mark Sansom, Prof Peter Hunter, Prof R Vaughan-Jones |
| Partnership Value | 89747 |
| Planned Dates: End Date | 2009-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2006-12-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |