Regulation of tissue inhibitors of matrix metalloproteases (TIMPs) expression in the gastric epithelium. (360G-Wellcome-074945_Z_04_A)
The aim of this project is to define the mechanisms by which H.pylori infection increases expression of tissue inhibitors of matrix metalloproteases (TIMPs) in gastric mucosal cells, and to determine the consequences for the mucosal remodelling that occurs with infection. The experimental plan is based on our capacity to culture human primary gastric epithelial cells and myofibroblasts transfected with promoter-reporter constructs, to study Helicobacter responses in mice (and determine if they are an useful model) and to identify putative substrates using 2-DG cells and mass spectrometry of selected spots (5,6,7).
Where is this data from?
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Grant Details
| Amount Awarded | 6396 |
| Applicant Surname | Michael |
| Approval Committee | Physiological Sciences Funding Committee |
| Award Date | 2006-09-20T00:00:00+00:00 |
| Financial Year | 2005/06 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 074945/Z/04/A |
| Lead Applicant | Miss Angharad Michael |
| Other Applicant(s) | Prof Alexei Tepikin |
| Partnership Value | 6396 |
| Planned Dates: End Date | 2008-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2004-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | North West |
| Sponsor(s) | Prof Alexei Tepikin |