Molecular and behavioural characterisation of mice over-expressing type 1 neuregulin-1. (360G-Wellcome-075407_Z_04_A)
Molecular and behavioural characterisation of mice over-expressing type I neuregulin-1 Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia, and increased expression of the NRG1 type 1 isoform occurs in the disease. The main aim of this study is to establish the extent to which overexpression of type 1 NRG1 in mice reproduces molecular, morphological, and behavioural features of schizophrenia. The work will also begin to reveal the normal neurobiological functions of type 1 NRG1, which are almost entirely unknown at present. Depending on progress, the project also aims to investigate the phenotype of mice overexpressing type IV NRG1, since this alternation is also associated with NRG1's genetic involvement in schizophrenia.
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Grant Details
| Amount Awarded | 17205 |
| Applicant Surname | Deakin |
| Approval Committee | Molecular and Cellular Neuroscience Funding Committee |
| Award Date | 2005-12-14T00:00:00+00:00 |
| Financial Year | 2005/06 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 075407/Z/04/A |
| Lead Applicant | Miss Inga Deakin |
| Partnership Value | 17205 |
| Planned Dates: End Date | 2009-03-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2005-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Dr Jeremy Taylor |