Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

An integrated quantitative virological and immunological approach to optimise treatment and define correlates of immune protection against cytomegalovirus in allograft recipients. (360G-Wellcome-078332_Z_05_Z)

In a unique collaboration with transplant clinicians we have produced a paradigm shift in understanding the pathogenesis of HCMV infection. Specifically, we have shown that: a) this virus replicates with rapid dynamics; b) it causes disease in individuals once a critical threshold value of viral load has been reached in the blood; c) patients with rapid replication have a HCMV-specific CD8+ immune defect ("specific interferon gamma impairment; SIGI") which precedes the onset of viraemia. These novel findings will be taken forward in four ways: i) we will conduct randomised controlled trials to optimise treatment based on real time measurement of HCMVviral load; ii) we will determine if SIGI explains why some patients have a slow response to treatment; iii) we will determine if reinfection with a different strain of HCMV can induce SIGI; iv) we will systematically extend immunological studies to determine if other specific immune responses against additional HCMV proteins, restricted by class I and class II HLA molecules, also correlate with full control of HCMV replication.


25 Oct 2005

Grant details
Amount Awarded 605793
Applicant Surname Griffiths
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2005-10-25T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Programme Grant
Internal ID 078332/Z/05/Z
Lead Applicant Prof Paul Griffiths
Other Applicant(s) Prof Vincent Emery, Prof Caroline Sabin, Prof Paul Klenerman
Planned Dates: End Date 2011-09-19T00:00:00+00:00
Planned Dates: Start Date 2006-04-20T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Additional data added by GrantNav