Characterisation and functional analysis of Hesx1-interacting proteins in mouse and human. (360G-Wellcome-078432_Z_05_Z)
Hesx1 is a conserved member of the paired-like class of homeobox genes, which is expressed in the rostral region of the developing vertebrate embryo, but isabsent in non-vertebrate species. Hesx1-deficient mice show defects in the forebrain and pituitary gland, and HESX1 mutations are associated with congenital hypopituitarism and septo-optic dysplasia (SOD) in humans. Therefore, it is now established that Hesx1/HESX1 is a critical developmental gene in both mouse and humans. However, little is known about the functions ofHesx1 at a molecular level, i.e., about its regulators, target genes and interacting proteins. To gain further knowledge on the molecular basis of forebrain and pituitary development in mouse and gain insights into the mechanisms underlying congenital hypopituitarism and SOD in humans, we have recently carried out a yeast two-hybrid screen, identified five Hesx1-interacting proteins and partially characterised these interactions. Themain goal of this study is to carry out a detailed characterisation of these interactions with the primary objective of understanding better how Hesx1
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Grant Details
Amount Awarded | 235911 |
Applicant Surname | Martinez-Barbera |
Approval Committee | Molecular and Cellular Neuroscience Funding Committee |
Award Date | 2005-10-20T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | Project Grant |
Internal ID | 078432/Z/05/Z |
Lead Applicant | Prof Juan Pedro Martinez-Barbera |
Other Applicant(s) | Prof Mehul Dattani |
Partnership Value | 235911 |
Planned Dates: End Date | 2009-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2006-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Andrew Copp |