TwinsUK Genetic Epidemiology Resource. (360G-Wellcome-079771_Z_06_Z)

This project aims to build on the existing TwinsUK resource. The currently held Wellcome FGI has funded development of the twin resource and the creation of a website and open access by researchers to limited twin data. We plan to ensure that the resource is investigated as thoroughly as possible, answering specific questions in a variety of fields, using well-designed studies in a cost-effective manner. In addition to maintaining and studying the existing phenotypes we plan: - Collection of new and longitudinal phenotypes eg. Adipose tissue, eye data, inflammatory markers - Linkage Study and statistical analysis on 2,500 pairs - Maintenance and consolidation of twin resource - Extending the use of the database and website development Key goals include: 1.Maintenance and consolidation of the twin resource by ensuring that the biological samples and phenotype databases are safely stored and available for widespread use; to retain motivation of the cohort through regular contact. 2. Make greater use of the resource by strengthening current relationships and forging new links with scientific collaborators and providing controlled access to the full genotypic information and selected phenotypes via the internet. 3. Extend the scientific utility of the resource by collecting new questionnaire data and biological samples.