Diurnal corticoid rhythms and regulation of neurogenesis in the adult hippocampus by fluoxetine. (360G-Wellcome-080048_Z_06_Z)
We have found that a diurnal rhythm in corticosterone in required for the stimulating action of fluoxetine on the proliferation of progenitor cells and thus increased neurogenesis in the dentate gyrus of the adult hippocampus. This application seeks to explore the mechanism for this effect. The approaches are: to explore possible changes in rhythm-flattened rats in : (i) 5HT1A and 5HT7 receptors (ii) the serotonin uptake receptor (iii) the expression of gluco- and mineralo-corticoid receptors (iv) the diurnal variation in clock genes in the dentate gyrus (v) the interactions between 5HT, nitric oxide and the corticoid rhythm (vi) the action of BDNF on proliferation and maturation of progenitor cells (vii) whether a behavioural response to fluoxetine (and other SSRIs) is also dependent on the presence of a corticoid rhythm.
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Grant Details
| Amount Awarded | 436176 |
| Applicant Surname | Herbert |
| Approval Committee | Neurosciences And Mental Health |
| Award Date | 2006-07-04T00:00:00+00:00 |
| Financial Year | 2005/06 |
| Grant Programme: Title | Project Grant |
| Internal ID | 080048/Z/06/Z |
| Lead Applicant | Prof Joseph Herbert |
| Partnership Value | 436176 |
| Planned Dates: End Date | 2010-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2006-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |