A genetic component to the INDEYE study of cataract and age-related macular degeneration in India . (360G-Wellcome-082571_Z_07_Z)
India accounts for a quarter of global blindness. The high rates and unique patterns of type of cataract in India are likely to be due to a combination of environmental and genetic factors. There has been exciting recent progress in genetic risk factors for age-related macular degeneration (AMD), but the role of various candidate genes in populations of non-European origin remain unresolved. INDEYE is a Wellcome Trust funded study of environmental risk factors for eye disease among 6000 older (60+) people in two centres in the north and south of India. We propose a genetic extension to the INDEYE study with four goals. Firstly, an additional sample of 3000 people aged between 40 and 59 years will be recruited. Secondly, DNA will be extracted for all 9000 participants. Thirdly, we will increase the sample size of AMD cases by recruiting an additional 500 cases to increase study power. Fourthly genetic association studies for both cataract and age related macular degeneration will be undertaken. The project will create a unique resource of several thousand genetic samples from a population based study in India with high quality digital lens and retinal photographs and full information on environmental risk factors.
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Grant Details
| Amount Awarded | 636156 |
| Applicant Surname | Fletcher |
| Approval Committee | Populations and Public Health Funding Committee |
| Award Date | 2007-05-02T00:00:00+00:00 |
| Financial Year | 2006/07 |
| Grant Programme: Title | Project Grant |
| Internal ID | 082571/Z/07/Z |
| Lead Applicant | Prof Astrid Fletcher |
| Other Applicant(s) | Dr P Sundaresan, Dr Ravindran Ravilla, Prof Dorothea Nitsch, Prof Liam Smeeth, Prof Usha Chakravarthy |
| Partnership Value | 636156 |
| Planned Dates: End Date | 2011-08-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-03-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |