Student elective for Timothy Hardy. (360G-Wellcome-083051_Z_07_Z)

Toll like Receptor-4 involvement in Airway Epithelial Wound Repair It is important to understand the regulatory mechanisms involved in airway epithelial mucosal repair, if we are to develop new therapeutic strategies to halt the progression of asthma when the disease first manifests itself in childhood. This project is premised on the hypothesis that dysregulated repair underpins the development of airway remodelling in asthma. More specifically, we propose that TLR-4 plays the key role in driving inflammation as part of the airway epithelial repair response to injury which is dysregulated in patients with inflammatory respiratory diseases, such as asthma.