Student elective for Meike Keil. (360G-Wellcome-083423_Z_07_Z)

£1,600

It has been known over 100 years that disorders in acid-base balance influence the contractility of cardiac muscle. While acidosis induces a decrease in the developed force of cardiac muscle by affecting every step of the excitation-contraction coupling pathway, including both the delivery of Ca2+ to the myofilaments and the response of the myofilaments to Ca2+, the effects of alkalosis on the contractile apparatus are not yet fully understood. Additionally, defined temporary shifts in pH, especially acidosis are protective on cardiac myocytes in acute and chronic hypoxia. And there is evidence that hypoxia at lower pH does not promote apoptosis or activate caspases in cardiac myocytes, but cardiomyocytes undergo extensive death when the extra cellular pH drops below 6.5. Furthermore, acidosis during early reperfusion prevents myocardial stunning or hypercontracture in perfused hearts. However to date, the range of acid base balance where myocardial protective effects remain effective is uncertain. Additionally, it is still controversial if there is a difference between respiratory or metabolic acidosis on protective properties. The aim of this study is to determine the impact of pH-shifts on myocardial protective effects under hypoxic conditions in the isolated heart, focussing on electrophysiological, mechanical, myocardial-metabolic and histological properties. Additional to the planning and implementation of a scientific experiment in an animal model, particular emphasis will be laid on achieving foundations in the physiology of circulation in relation to acid-base balance.

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Grant Details

Amount Awarded 1600
Applicant Surname Campbell
Approval Committee Neurosciences And Mental Health
Award Date 2007-05-28T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Studentship: Inactive scheme
Internal ID 083423/Z/07/Z
Lead Applicant Prof John Campbell
Partnership Value 1600
Planned Dates: End Date 2007-12-24T00:00:00+00:00
Planned Dates: Start Date 2007-06-25T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West