The role of hepatic myofibroblasts in liver injury and regeneration. (360G-Wellcome-084961_Z_08_Z)
This project will use a human recombinant single chain antibody to target hepatic myofibroblasts (HMs) in vivo. The antibody will be conjugated to gliotoxin, a compound that stimulates the apoptosis of HM. Unpublished data demonstrate that the antibody-conjugate specifically stimulates the apoptosis of HMs in vivo in animals with liver fibrosis. This project will: 1) Determine the effects of HM depletion on inflammatory, wound-healing and regenerative responses to acute liver injuries. 2) Determine whether HM depletion affects compensatory hepatocyte regeneration. 3) Determine whether HM depletion will promote reversal of fibrosis and permit regeneration of hepatocytes in the context of fibrosis and sustained liver injury.
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Grant Details
| Amount Awarded | 264114 |
| Applicant Surname | Wright |
| Approval Committee | Physiological Sciences Funding Committee |
| Award Date | 2008-04-22T00:00:00+00:00 |
| Financial Year | 2007/08 |
| Grant Programme: Title | Project Grant |
| Internal ID | 084961/Z/08/Z |
| Lead Applicant | Prof Matthew Wright |
| Other Applicant(s) | Dr Fiona Oakley, Prof Alastair Burt, Prof Derek Mann |
| Partnership Value | 264114 |
| Planned Dates: End Date | 2012-02-29T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | North East |