Early determinants of reproduction function in migrant populations. (360G-Wellcome-085010_Z_08_Z)

Adrenarche represents the gradual maturation of the adrenal gland and is an important stage (at approximately 8-10 years) presaging puberty. Relatively little work has been undertaken examining the process in relation to later reproductive function and in particular to pubertal maturation. A recent migrant study of Bangladeshis showed significant differences between Bangladeshi migrant groups and sedentees in menarcheal age and later adult levels of progesterone. Women who migrated < 8 had significantly higher levels of progesterone suggesting a critical developmental window influencing later reproductive function. Further hormonal research among children would lead to a better understanding of adrenarche's role in the reproductive lifecourse.