Kinetoplastid Bioinformatics: Expansion of GeneDB to Support and Enable Post-Genomic Research. (360G-Wellcome-085822_A_08_Z)

The emergence of genome sequences has revolutionised the molecular and cell biology of protozoan pathogens and has led to an optimism that progress towards developing treatments for these neglected diseases is being accelerated. The aim of this proposal is to expand the protozoan genome database resource, GeneDB, to facilitate questioning of both current and emerging genomes and large functional genomic datasets. The key objectives are to improve annotation of current and emerging genomes, to in tegrate functional genomics datasets, to develop complex querying tools and to facilitate greater integration into the research community. The expansion of GeneDB will be undertaken using the current expertise in annotation and also by collaboration with other database resources to share expertise. In particular, tools for large dataset querying will be developed in collaboration with the ApiDB protozoan genome resource using their expertise. This collaboration will also bring about the ability to query large numbers of protozoan genomes from both resources. The aim of improved communication with the research community will result from interactive curation, greater outreach and the development of a training website. The outcome will be a resource that enables and accelerates research in labs around the world.