iNKT cells as key mediators of inflammation - Dissecting the role played by iNKT cells in haematopoiesis. (360G-Wellcome-086322_Z_08_A)
The overall aim of this research programme is to investigate the role played by invariant NKT cells in myelopoiesis; in influencing the differentiation of cells along the myeloid lineage, key players in inflammation. Research will be divided into three complementing programmes: Objective 1: Identification of leukocyte populations which require iNKT cells for differentiation Objective 2: Test the hypothesis that iNKT cells enhance the speed of haematologic recovery Objective 3: Dissect the molecular mechanisms of iNKT cell-mediated MDSC differentiation Significance: iNKT cells are at the interface between the innate and adaptive immune responses. Understanding the mechanisms by which iNKT cells modulate haematopoiesis and inflammation will be of importance to develop strategies to stimulate myelopoesis and harness iNKT cell activation during inflammation.
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Grant Details
| Amount Awarded | 23687 |
| Applicant Surname | Yip |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2010-01-18T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 086322/Z/08/A |
| Lead Applicant | Mr Ronald Yip |
| Partnership Value | 23687 |
| Planned Dates: End Date | 2012-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-02-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Keith Gull |