Functional organization, regulation and cellular roles of elongation factor (eEF) 2 kinase. (360G-Wellcome-086688_Z_08_Z)

£1,334,655

This proposal concerns the unusual protein kinase that regulates the activity of elongation factor eEF2, i.e., eEF2 kinase (eEF2K). It builds upon recent advances in this area in the applicants laboratories. The main goals of this Programme are: 1. to establish how signalling through mTOR complex 1 (mTORC1) regulates the activity of eEF2K; in particular to identify the kinase that acts at Ser78 in eEF2K; 2. to determine how (auto)phosphorylation controls eEF2K activity and to identify add itional regulatory phosphorylation sites within eEF2K; 3. to elucidate how other regulatory inputs, such as pH, control eEF2K and their importance for the control of eEF2 and protein synthesis; 4. (i) to study the structures and functions of different domains within eEF2K and (ii) to investigate the interactions and interplay between them in the function of eEF2K and its control; 5. to explore the roles of eEF2K and the phosphorylation of eEF2 in regulating protein synthesis in response to hormones and growth factors or under conditions of cellular stress such as ATP depletion. This exploits the availability of cells, tissues and animals that lack eEF2K activity; 6. to determine whether eEF2K plays additional physiological roles and identify new substrates for this kinase.

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Grant Details

Amount Awarded 1334655
Applicant Surname Proud
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2008-11-10T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Programme Grant
Internal ID 086688/Z/08/Z
Lead Applicant Prof Christopher Proud
Other Applicant(s) Dr Joern Werner
Partnership Value 1334655
Planned Dates: End Date 2014-11-30T00:00:00+00:00
Planned Dates: Start Date 2009-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East