Functional organization, regulation and cellular roles of elongation factor (eEF) 2 kinase. (360G-Wellcome-086688_Z_08_Z)
This proposal concerns the unusual protein kinase that regulates the activity of elongation factor eEF2, i.e., eEF2 kinase (eEF2K). It builds upon recent advances in this area in the applicants laboratories. The main goals of this Programme are: 1. to establish how signalling through mTOR complex 1 (mTORC1) regulates the activity of eEF2K; in particular to identify the kinase that acts at Ser78 in eEF2K; 2. to determine how (auto)phosphorylation controls eEF2K activity and to identify add itional regulatory phosphorylation sites within eEF2K; 3. to elucidate how other regulatory inputs, such as pH, control eEF2K and their importance for the control of eEF2 and protein synthesis; 4. (i) to study the structures and functions of different domains within eEF2K and (ii) to investigate the interactions and interplay between them in the function of eEF2K and its control; 5. to explore the roles of eEF2K and the phosphorylation of eEF2 in regulating protein synthesis in response to hormones and growth factors or under conditions of cellular stress such as ATP depletion. This exploits the availability of cells, tissues and animals that lack eEF2K activity; 6. to determine whether eEF2K plays additional physiological roles and identify new substrates for this kinase.
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Grant Details
Amount Awarded | 1334655 |
Applicant Surname | Proud |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2008-11-10T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | Programme Grant |
Internal ID | 086688/Z/08/Z |
Lead Applicant | Prof Christopher Proud |
Other Applicant(s) | Dr Joern Werner |
Partnership Value | 1334655 |
Planned Dates: End Date | 2014-11-30T00:00:00+00:00 |
Planned Dates: Start Date | 2009-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |