Support for a Wellcome Trust/Academy of Medical Science Internship (360G-Wellcome-086781_Z_08_B)
During my Ph.D. I shall further explore in role of CaMKil and CASK in synaptic function and learning using Drosophila. I will also test to see if hCASK mutations alter CASK protein interactions at the synapse, such as its ability to dynamically regulate CaMKII autophosphorylation, and the effects of these mutations results in impaired on synaptic function and learning. This work could allow important insights into the pathology of mental retardation due to CASK mutations, and how the molecular machinery that is involved in synaptic plasticity is organised and regulated during learning. These aims are summarized below; Science l. 2. Investigate if the synaptic and behavioural function of CASK is conserved between humans and Drosophila. Use Drosophila to model how CASK disease-causing mutations affect synaptic function and behaviour.
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Grant Details
| Amount Awarded | 5330 |
| Applicant Surname | Gillespie |
| Approval Committee | PhD Studentships |
| Award Date | 2012-03-19T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 086781/Z/08/B |
| Lead Applicant | Mr John Gillespie |
| Partnership Value | 5330 |
| Planned Dates: End Date | 2012-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South West |
| Sponsor(s) | Prof Peter Cullen |