King's College London Medical Engineering Centre. (360G-Wellcome-088641_Z_09_Z)

The King's College London Medical Engineering Centre aims to deliver word- class excellence in engineering and physical sciences by breaking down the barriers between physical sciences and biomedicine as well as facilitatingcloser partnership between academia and industry. Focusing on the important area of medical imaging the aim is also to extend clinical translation into outcome and efficacy studies to ensure wider dissemination of physical scienceresearch into clinical practice. The proposal has a number of key general initiatives including, a multi-disciplinary MSc and MRes programme, pump priming of joint academic industrial research initiatives and collaboration with luminary international research groups. The bulk of the proposal is six specific scientific programmes that bring together strong basic science with clinical translation in the setting of an Academic Health Science Centre. The programs are: 1- Robotic radiation-free imaging guidance system for ablation of arrhythmias; 2- Biophysical modeling of myocardial perfusion and coronary artery disease; 3- Simultaneous PET/MR imaging of atherosclerosis using novel molecular and cellular contrast agents; 4- A pretargeted nanoparticle-based platform for molecular imaging and targeted radionuclide therapy of cancer; 5-Rebuilding faces a programme of tissue engineering and 6- A machine learning approach to the analysis of neuroimaging data.