The genetic basis of primary biliary cirrhosis. (360G-Wellcome-088805_Z_09_Z)
Primary biliary cirrhosis (PBC) is a chronic, cholestatic liver disease which, in many cases, leads to cirrhosis and liver failure. PBC mainly affects middle-aged and older women; the prevalence in women > 40 years is approximately 950 per million. There is no effective pharmacotherapy that retards disease progression. Liver transplant for PBC-related liver failure is the only effective treatment but disease may recur in the graft. There is strong evidence that PBC is a complex disease. The only consistent finding from genetic studies is weak association between PBC and HLA-DR8. A DNA collection adequate for a genome-wide association study (GWAS) has been established via the formation of a UK PBC Consortium consisting of 52 centres and all 7 UK Liver Transplant Units. This DNA collection will be used to undertake a GWAS in collaboration with the WTCCC.
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Grant Details
| Amount Awarded | 7800 |
| Applicant Surname | Sandford |
| Approval Committee | Genome-Wide Association Studies in Common Disease Committee 2008 |
| Award Date | 2009-04-01T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | Programme Grant |
| Internal ID | 088805/Z/09/Z |
| Lead Applicant | Dr Richard Sandford |
| Other Applicant(s) | Dr George Mells, Dr Michael Heneghan, Dr Peter Donaldson, Prof David Jones, Prof Graeme Alexander, Prof Heather Cordell, Prof James Neuberger |
| Partnership Value | 7800 |
| Planned Dates: End Date | 2010-08-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-09-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |