Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes. (360G-Wellcome-088806_Z_09_Z)

Our goal is to contribute to understanding mechanisms underlying the association of pregnancy phenotypes with future cardiovascular and metabolic phenotypes in women and their offspring. We will test genetic variation on the Illumina 660W-quad BeadChip for association with pregnancy and later-life phenotypes. Pregnancy phenotypes will include weight gain, blood pressure change, hypertensive disorder of pregnancy (HDP), cholesterol, smoking, diet and alcohol. Later-life phenotypes in mothers and offspring will include fat mass, carotid intima media thickness, blood pressure, glucose, insulin, lipids, smoking, diet, physical activity and alcohol. Our sample size of 7,500-10,100 will enable detection of quantitative trait loci responsible for small proportions of the variance in the continuous phenotypes we will examine: 80% power at = 10-7 to detect 0.35-0.58%. For HDP our study (N=1,950 cases) has 80% power to detect a 1.22 odds ratio at = 10-7. We have agreement to complete from se veral cohorts with relevant phenotypes in mothers and offspring and the ability to complete rapid genotyping to complete replication studies (N=44,900). With these additional 44,900 individuals and our contribution to an existing consortium examining genome-wide data in relation to HDP we will have considerable power to detect robust associations.