Identification and characterisation of genes involved in spore germination of Clostridium difficile. (360G-Wellcome-089875_Z_09_A)
The aim of this project is to study the temporal expression of genes during C. difficile endospore germination. The objectives are: 1.1. To identify genes implicated in endospore germination, with a particular interest in genes encoding components of the cell wall 1.2. To construct gene knock-outs and use gene knock-down technologies to study the role of specific genes in germination 1.3. To analyse endospores of knock-out and knock-down strains for their ability to germinate in vitro as well as in vivo using a mouse model of infection.
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Grant Details
| Amount Awarded | 15241 |
| Applicant Surname | Dembek |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2011-01-17T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 089875/Z/09/A |
| Lead Applicant | Mr Marcin Dembek |
| Partnership Value | 15241 |
| Planned Dates: End Date | 2013-01-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-02-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Murray Selkirk |