Computational & experimental studies of riboswitches. (360G-Wellcome-090147_Z_09_Z)
This project aims to combine computational and experimental methods to further our understanding of how riboswitches interact with their cognate ligands, and how we can use sequence, structural and genomic context information to predict riboswitches in genomic sequences. Objectives of this project include: a) The development of a computational method to identify candidate sequences for new classes of riboswitches. b) Obtaining crystal structures of riboswitches in complex with cognate ligands in an effort to understand the mechanisms of recognition. c) Using biophysical methods to measure the binding affinity of riboswitches to their ligands. d) Exploring riboswitch turnover by specialised proteins using crystallography and biochemical assays.
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Grant Details
| Amount Awarded | 152244 |
| Applicant Surname | Patschull |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-07-21T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 090147/Z/09/Z |
| Lead Applicant | Miss Anathe Patschull |
| Partnership Value | 152244 |
| Planned Dates: End Date | 2013-09-27T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-09-28T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Gabriel Waksman |