Pursuing a multi-level understanding of memory and motivation. (360G-Wellcome-090924_Z_09_Z)
The ability to appropriately direct behaviour using our memories is something we take for granted. However, in certain disease-states, such as affective disorders and addiction, our motivational control goes awry and behaviour runs amok. My goal is to understand detailed neural mechanisms of memory and motivation. We will use state-of-the-art genetics, physiology and behaviour to interrogate the relatively simple nervous system of the fruit fly Drosophila at the molecular, cellular and neural ne twork level. We will identify and characterize neural circuits that are modified by experience, and that are required for memory formation, consolidation and retrieval. We will profile gene expression in the relevant neurons before and after training using microarrays and will use neuron-specific transgenic RNA-interference with behavioural assays to find conserved memory-relevant genes. Appetitive memory is only efficiently retrieved in hungry flies and we have discovered the neurons that are c ritical for this motivational control. We will use a combination of genetics, behaviour and physiology to understand the detailed mechanisms that the motivational states of hunger and satiety utilize to conditionally alter neural circuit properties and expression of adaptive behaviour.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 1625197 |
Applicant Surname | Waddell |
Approval Committee | Basic Science Interview Committee |
Award Date | 2010-03-22T00:00:00+00:00 |
Financial Year | 2009/10 |
Grant Programme: Title | Senior Research Fellowship Basic |
Internal ID | 090924/Z/09/Z |
Lead Applicant | Prof Scott Waddell |
Partnership Value | 1625197 |
Planned Dates: End Date | 2016-10-31T00:00:00+00:00 |
Planned Dates: Start Date | 2011-11-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Gero Miesenboeck |