The placental glucocorticoid barrier: regulation by corticotropin-releasing hormone (CRH) during inflammation. (360G-Wellcome-091450_Z_10_Z)
During human pregnancy, the placenta expresses complex machinery to dynamically control (and limit) fetal exposure to glucocorticoids. Since this system is sensitive to the actions of inflammatory molecules, we hypothesize that in pregnancies associated with inflammatory disorders, this placental glucocorticoid (GC) barrier might be specifically targeted and that placentally-derived corticotropin-releasing hormone (CRH) might play a key role in adaptation to dysregulated inflammatory responses. The aim of this project is to elucidate the role of CRH in the regulation of placental signalling machinery controlling GC bioactivity in normal placenta and how this system responds to states of inflammatory disease.
Where is this data from?
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Grant Details
| Amount Awarded | 70000 |
| Applicant Surname | Hein |
| Approval Committee | WT/NIH Four Year PhD Programme Interview Committee |
| Award Date | 2010-01-27T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | WT/NIH Four Year PhD Studentship |
| Internal ID | 091450/Z/10/Z |
| Lead Applicant | Miss Anna Hein |
| Partnership Name | Wellcome Trust-NIH PhD Studentships |
| Partnership Value | 70000 |
| Planned Dates: End Date | 2014-10-03T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-10-04T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | West Midlands |
| Sponsor(s) | Prof John Davey |