The relationship of the menopausal transition to healthy aging and chronic disease risk. (360G-Wellcome-092830_Z_10_Z)
To complement an existing profile of work concerned with the relationship of women s reproductive heath and her healthy ageing, in the current proposal we will determine the role of the menopausal transition on healthy ageing and chronic disease risk. Data from the mothers in ALSPAC, together with other collaborating cohorts, will be used. Key goals that will be achieved are: 1. Determine patterns of change and inter-relationships in sex hormones, physical and cognitive capability, mental hea lth, cortical and trabecular bone density, fat and lean mass, blood pressure, fasting glucose, insulin and lipids as women go through the menopause. 2. Identify temporal and inter-individual variation in DNA methylation as women go through the menopause. 3. Determine the associations of earlier markers of women s reproductive health and their earlier lifestyle characteristics with menopausal age and menopausal transition changes. 4. Identify genetic variants that are robustly associated wi th variation in age at menopause and sex hormone levels, and use these to explore the extent to which these are causally related to cardiovascular and musculoskeletal health and physical and cognitive function. 5. Provide a detailed intergenerational resource that can be used by a wide-range of scientists to improve understanding of women s health.
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Grant Details
Amount Awarded | 1289829 |
Applicant Surname | Lawlor |
Approval Committee | Populations and Public Health Funding Committee |
Award Date | 2010-10-20T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Programme Grant |
Internal ID | 092830/Z/10/Z |
Lead Applicant | Prof Deborah Lawlor |
Other Applicant(s) | Dr Susan Ring, Dr Tom Palmer, Prof Abigail Fraser, Prof Caroline Relton, Prof George Davey Smith, Prof Jonathan Tobias, Prof Kate Tilling, Prof Naveed Sattar, Prof Scott Nelson |
Partnership Value | 1289829 |
Planned Dates: End Date | 2017-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2011-07-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South West |