The relationship of the menopausal transition to healthy aging and chronic disease risk. (360G-Wellcome-092830_Z_10_Z)

£1,289,829

To complement an existing profile of work concerned with the relationship of women s reproductive heath and her healthy ageing, in the current proposal we will determine the role of the menopausal transition on healthy ageing and chronic disease risk. Data from the mothers in ALSPAC, together with other collaborating cohorts, will be used. Key goals that will be achieved are: 1. Determine patterns of change and inter-relationships in sex hormones, physical and cognitive capability, mental hea lth, cortical and trabecular bone density, fat and lean mass, blood pressure, fasting glucose, insulin and lipids as women go through the menopause. 2. Identify temporal and inter-individual variation in DNA methylation as women go through the menopause. 3. Determine the associations of earlier markers of women s reproductive health and their earlier lifestyle characteristics with menopausal age and menopausal transition changes. 4. Identify genetic variants that are robustly associated wi th variation in age at menopause and sex hormone levels, and use these to explore the extent to which these are causally related to cardiovascular and musculoskeletal health and physical and cognitive function. 5. Provide a detailed intergenerational resource that can be used by a wide-range of scientists to improve understanding of women s health.

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Grant Details

Amount Awarded 1289829
Applicant Surname Lawlor
Approval Committee Populations and Public Health Funding Committee
Award Date 2010-10-20T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title Programme Grant
Internal ID 092830/Z/10/Z
Lead Applicant Prof Deborah Lawlor
Other Applicant(s) Dr Susan Ring, Dr Tom Palmer, Prof Abigail Fraser, Prof Caroline Relton, Prof George Davey Smith, Prof Jonathan Tobias, Prof Kate Tilling, Prof Naveed Sattar, Prof Scott Nelson
Partnership Value 1289829
Planned Dates: End Date 2017-06-30T00:00:00+00:00
Planned Dates: Start Date 2011-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West