Systems neuroscience: From networks to behaviour - Modulation of prefrontal cortex circuits in vivo and in vitro in normal animals and rodent models of schizophrenia. (360G-Wellcome-092994_Z_10_A)

The prefrontal cortex (PFC) is involved in many higher cognitive functions including working memory, attention and planning. Neuromodulators, such as the monoamines dopamine and serotonin play a key role in regulating these functions and are also central to many diseases associated with PFC dysfunction, including addiction and schizophrenia. In addition, the neuromodulator systems are also the targets of treatment for these conditions. Despite this key role the mechanisms of how the different neuromodulator systems alter PFC circuit function are still unclear and this proposal aims to further our understanding of the role of these key neuromodulators in the PFC.