Delineation of brain-derived-neurotropic factor (BDNF) neurons modulating energy balance. (360G-Wellcome-093566_Z_10_A)
Aim 1: (a) To characterize the regulation of hypothalamic brain-derived-neurotrophic factor (BDNF) expression by serotonin and melanocortin compounds and (b) determine whether BDNF is required for serotonin and melanocortin compounds to elicit effects on energy balance. Aim 2: To characterize the effect of ventromedial nucleus of the hypothalamus (VMN) steroidogenic factor 1 (SF-1) BDNF-expressing neurons on the effect of serotonin and melanocortin compounds modulating energy balance. Aim 3: To characterise the specific effect of VMN SF-1 BDNF-expressing neurons on energy balance.
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Grant Details
| Amount Awarded | 69285 |
| Applicant Surname | Burke |
| Approval Committee | PhD Studentships |
| Award Date | 2012-03-19T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 093566/Z/10/A |
| Lead Applicant | Mr Luke Burke |
| Partnership Value | 69285 |
| Planned Dates: End Date | 2014-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-03-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Sir Stephen O'Rahilly |