Functional and molecular characterisation of human keratin 9 to further develop RNAi-based therapeutics for EPPK (360G-Wellcome-093709_Z_10_Z)
The primary aim of this research project is to gain a better understanding of the functional importance and molecular activities of KRT9 in the palmoplantar epidermis so that we may further develop our potential RNAi-based therapeutics for Epidermolytic Palmoplantar Keratoderma (EPPK) into clinically applicable treatments. To this end, we aim to: 1. Define the functional importance of KRT9 in the palmoplantar epidermis via generation and characterization of KRT9 knockout mice. 2. Establish an in vitro PPK culturing system for evaluating novel therapeutics and characterizing the molecular activities of KRT9. 3. Explore and develop in vivo siRNA delivery methodologies for therapeutic treatment of EPPK.
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Grant Details
| Amount Awarded | 143440 |
| Applicant Surname | Fu |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2010-06-14T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 093709/Z/10/Z |
| Lead Applicant | Mr Dun Fu |
| Partnership Value | 143440 |
| Planned Dates: End Date | 2014-09-05T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-09-06T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Paul Crocker |