Differential leukocyte counts and the prognosis of specific coronary phenotypes. (360G-Wellcome-093830_Z_10_Z)

Background: Leukocyte counts are routinely measured in coronary disease and are related to prognosis, but the shape, strength and significance of such relationships, particularly with regard to prognosis of specific coronary phenotypes, are unclear. In addition, there is a need for better risk prediction tools for stable angina. Aims: To investigate the association of counts of leukocyte subtypes with prognosis in patients with stable coronary disease. To examine differences in the shape and strength of the association by start point and endpoint, to assess whether any inference can be made for causality. To develop and validate a risk prediction model for patients with stable coronary disease, and assess the incremental value of leukocyte counts in such a model. To use prognostic risk information for stable coronary disease to explore variation in drug treatment effects. Methods: Analysis of new bespoke prospective cohort study (recruiting patients from cardiology clinics and a ngiography lists), and analysis of large database of linked routinely collected data including the General Practice Research Database (GPRD, 4.7 million patients), the Myocardial Infarction National Audit Project (MINAP, 25,000 episodes linked to GPRD), Hospital Episode Statistics (HES) and death registrations.