A Versatile, Minimally-Invasive Treatment for Cancer: Applying Temporal Focusing to Photodynamic Therapy. (360G-Wellcome-093831_Z_10_Z)
The goal of this research is to demonstrate that temporal focusing combined with two-photon absorption and photodynamic therapy can treat a tumour that is located within a mass of tissue. In year one, the goal will be to construct the optical setup, characterise it, demonstrate automated control of the illumination parameters, and demonstrate the ability to selectively illuminate regions of a test mass such as a dye-doped gel block. In year two, the goal will be to optimise the optical se tup, and selectively generate singlet oxygen at a defined site with high spatial resolution. Diagnostic imaging methods such as stimulated Raman scattering or optical coherence tomography will be investigated for incorporation. In year three, the effectiveness of the system will be tested on cell-lines in order to demonstrate that the cells can be selectively targeted. Diagnostic imaging will be finalised and incorporated, allowing a mixture of healthy and cancerous cells (taken from cell-lin es) to be differentiated, and the cancerous cells killed. The final year will be back in the UK; the system will be reconstructed (with any modifications deemed necessary). Subject to a successful outcome, applications will be made to test the system in animal models and possibly clinical trials.
£97,476 06 Dec 2010