Molecular, genetic and lifecourse epidemiology. (360G-Wellcome-093847_Z_10_Z)
1. I hypothesize that common upstream regulatory pathways of CREB/AhR regulate FSCN1 promoter activity in carcinomas. 2. I hypothesize that CREB/AhR regulates the expression of genes involved in the cancer invasion "program" which are associated with prostate cancer progression. 3. I hypothesize that CREB/AhR and miRNAs act in concert to regulate fascin-1 protein levels in carcinomas. 4. 1 hypothesize that the up-regulation of fascin-1 protein is associated with prostate cancer progression. In addition, I hypothesize that the expression or activation status of regulators of fascin-1 expression such as CREB/AhR and miRNAs are associated with prostate cancer progression. I will test my hypotheses by applying a combination of cell biology and epidemiology approaches, in order to both understand the regulation of FSCN1 in cancer and the translational potential of FSCN1 and its regulators as potential prognostic cancer biomarkers. My unique first year training programme has equipped me with the wide set of skills I require to combine both approaches within a single, unifying PhD project.
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Grant Details
| Amount Awarded | 143090 |
| Applicant Surname | Tan |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2010-07-13T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 093847/Z/10/Z |
| Lead Applicant | Dr Vanessa Tan |
| Partnership Value | 143090 |
| Planned Dates: End Date | 2014-10-03T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-10-04T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South West |
| Sponsor(s) | Prof George Davey Smith |