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Training Programme in Translational Medicine and Therapeutics at the University of Cambridge: 'Comprehensive analysis of structural rearrangements in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.' (360G-Wellcome-095224_Z_11_Z)

Oesophageal adenocarcinoma has a dismal prognosis; median survival is <1 year. It is thought that chromosomal rearrangements (including inversions, translocations, deletions and insertions) may play as much of a role in the development of cancer as the more thoroughly studied point mutations. Paired-end Sequencing allows rapid analysis of virtually all breakpoints in a tumour to a resolution of 500bp. Simultaneously it provides highly accurate copy number data comparable to that from arrayCGH. The Barrett's-?Dysplasia-?OAC is a well recognised paradigm. Ease of accessibility and longitudinal sampling as part of standard clinical practice provides a unique opportunity to study the biology of progression in epithelial carcinoma. Key Goals 1. Investigate structural rearrangements and copy number abnormalities involved in the genesis of oesophageal carcinoma in a small group of carefully selected patients with samples representing Barrett's oesophagus, Oesophageal adenocarcinoma and normal tissue from the same patient. 2. Confirm the importance of individual structural rearrangements by screening a large collection of primary tissue samples and comparison with clinical outcome 3. Functional assessment of potential therapeutic targets 4. Investigate the potential of personalised assays, based on unique structural rearrangements, for tumour cell-free DNA in patient serum as markers of disease status


30 Nov 2010

Grant details
Amount Awarded 97095
Applicant Surname Weaver
Approval Committee Neurosciences And Mental Health
Award Date 2010-11-30T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title Translational Medicine & Therapeutics Programme Clinical PhD Fellow
Internal ID 095224/Z/11/Z
Lead Applicant Mr Jamie Weaver
Planned Dates: End Date 2013-08-29T00:00:00+00:00
Planned Dates: Start Date 2010-08-30T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Morris Brown
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