Genomic imprinting and the epigenetic control of genome function. (360G-Wellcome-095606_Z_11_Z)
Our research uses insights gained from genomic imprinting to generate and answer hypothesis-driven fundamental questions about the epigenetic control of mammalian gene expression both within and outside imprinted domains. This is possible through the use of in vivo mouse models combined with molecular genetic studies applied to an integrated holistic programme that links genome, epigenome, and transcriptional control to developmental consequences and physiological outcome in the whole organism. The research is organized into three integrated themes: 1. Establishment and maintenance of the epigenetic programme during development. 2. The epigenetic control of genome function lessons from imprinting. 3. Environment, development and disease.
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Grant Details
Amount Awarded | 2008652 |
Applicant Surname | Ferguson-Smith |
Approval Committee | Science Interview Panel |
Award Date | 2011-05-10T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 095606/Z/11/Z |
Lead Applicant | Prof Anne Ferguson-Smith |
Partnership Value | 2008652 |
Planned Dates: End Date | 2018-11-30T00:00:00+00:00 |
Planned Dates: Start Date | 2011-12-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |