Genomic imprinting and the epigenetic control of genome function. (360G-Wellcome-095606_Z_11_Z)

£2,008,652

Our research uses insights gained from genomic imprinting to generate and answer hypothesis-driven fundamental questions about the epigenetic control of mammalian gene expression both within and outside imprinted domains. This is possible through the use of in vivo mouse models combined with molecular genetic studies applied to an integrated holistic programme that links genome, epigenome, and transcriptional control to developmental consequences and physiological outcome in the whole organism. The research is organized into three integrated themes: 1. Establishment and maintenance of the epigenetic programme during development. 2. The epigenetic control of genome function lessons from imprinting. 3. Environment, development and disease.

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Grant Details

Amount Awarded 2008652
Applicant Surname Ferguson-Smith
Approval Committee Science Interview Panel
Award Date 2011-05-10T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title Investigator Award in Science
Internal ID 095606/Z/11/Z
Lead Applicant Prof Anne Ferguson-Smith
Partnership Value 2008652
Planned Dates: End Date 2018-11-30T00:00:00+00:00
Planned Dates: Start Date 2011-12-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England