Structural role of BET bromodomains in transcription. (360G-Wellcome-095751_Z_11_Z)
This project aims to address the structural role of BET bromodomains in transcription initiation and the implications of disrupting this role in disease, when for example BETs are found fused to the NUT (nuclear protein in testis) protein or when they are associated to viral oncoproteins. To do so I will employ high throughput structural biology techniques to study BET bromodomains, aiming to establish an interaction map with their substrates, understand the molecular details of substrate intera ctions, explain synergy between multiple BET dromodomain modules, explore the molecular and structural basis of their interactions with the positive transcription elongation factor b (P-TEFb), structurally characterize their oncogenic fusions to NUT and probe the molecular and structural basis of their interactions with viral oncoproteins.
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Grant Details
| Amount Awarded | 1036653 |
| Applicant Surname | Filippakopoulos |
| Approval Committee | Basic Science Interview Committee |
| Award Date | 2011-06-22T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | Research Career Development Fellowship |
| Internal ID | 095751/Z/11/Z |
| Lead Applicant | Dr Panagiotis Filippakopoulos |
| Partnership Value | 1036653 |
| Planned Dates: End Date | 2017-06-01T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-12-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Sir Peter Ratcliffe |