Studies of linear ubiquitin and different modes of cell death induction by TNFfamily members in aetiology and treatment of auto-immunity (360G-Wellcome-096831_Z_11_A)
I. What are the inducers, mechanisms and immunological consequences of proinflammatorycell death when ubiquitin-signalling is perturbed and how can they beinhibited?II. Can type-II auto-immunity be treated by preventing pro-inflammatory cell death and/orits immunological consequences?III. Can we identify auto-immune patients who may benefit from a therapy that preventsnecroptosis and/or its pro-inflammatory consequences?
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Grant Details
| Amount Awarded | 2654537 |
| Applicant Surname | Walczak |
| Approval Committee | Science Interview Panel |
| Award Date | 2011-10-04T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 096831/Z/11/A |
| Lead Applicant | Prof Henning Walczak |
| Partnership Value | 2654537 |
| Planned Dates: End Date | 2018-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-01-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |