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Studies of linear ubiquitin and different modes of cell death induction by TNFfamily members in aetiology and treatment of auto-immunity (360G-Wellcome-096831_Z_11_A)

I. What are the inducers, mechanisms and immunological consequences of proinflammatorycell death when ubiquitin-signalling is perturbed and how can they beinhibited?II. Can type-II auto-immunity be treated by preventing pro-inflammatory cell death and/orits immunological consequences?III. Can we identify auto-immune patients who may benefit from a therapy that preventsnecroptosis and/or its pro-inflammatory consequences?


04 Oct 2011

Grant details
Amount Awarded 2654537
Applicant Surname Walczak
Approval Committee Science Interview Panel
Award Date 2011-10-04T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Investigator Award in Science
Internal ID 096831/Z/11/A
Lead Applicant Prof Henning Walczak
Planned Dates: End Date 2018-12-31T00:00:00+00:00
Planned Dates: Start Date 2013-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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