Studies of linear ubiquitin and different modes of cell death induction by TNFfamily members in aetiology and treatment of auto-immunity (360G-Wellcome-096831_Z_11_A)
I. What are the inducers, mechanisms and immunological consequences of proinflammatorycell death when ubiquitin-signalling is perturbed and how can they beinhibited?II. Can type-II auto-immunity be treated by preventing pro-inflammatory cell death and/orits immunological consequences?III. Can we identify auto-immune patients who may benefit from a therapy that preventsnecroptosis and/or its pro-inflammatory consequences?
£2,654,537 04 Oct 2011