Identification of novel gd T-cell ligands cells using a forward genetic screenin haploid human cells. (360G-Wellcome-097033_Z_11_Z)

£155,810

ãä T cells are a unique subset of T cells which do not require antigen processing and subsequent presentation by major histocompatibility complex (MHC) molecules, but instead recognise antigens directly. However, very little is known about the mechanisms of ãä T-cell ligand recognition. Therefore, we propose a novel gene-trap mutagenesis approach in human haploid cells to identify novel ãä T-cell ligands. There are four primary objectives that need to be met to carry out a successful screen using human ãä T cells and the near-haploid KBM7 cells: (i) establish specific ãä T-cell lines of interest; (ii) prove susceptibility of KBM7 cells to lysis by the particular ãä T-cell subset; (iii) mutagenise the KBM7 cells and

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Grant Details

Amount Awarded 155810
Applicant Surname Tchasovnikarova
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2011-07-12T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 097033/Z/11/Z
Lead Applicant Ms Iva Tchasovnikarova
Partnership Value 155810
Planned Dates: End Date 2015-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Paul Lehner