Structural investigation of the Hepatitis C Virus capsid assembly (360G-Wellcome-097300_Z_11_Z)
Hepatitis C Virus infection can cause chronic liver pathologies such as cirrhosis and hepatocellular carcinoma. With at least 130 million people infected world wide, the drive to understand and treat this virus is pressing. The core protein is responsible for the formation of the capsid that protects the viral genome. However very little is known about the structural information of the capsid. This project aims to elucidate the three-dimensional structure of the capsid by electron microscopy and X-ray crystallography. Further biophysical characterisation of the capsid will help to further our understanding of the molecular details of this medically relevant virus. The project then aims to discover and characterise novel inhibitors of assembly as a potential antiviral therapy.
£156,774 31 Aug 2011