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Structural investigation of the Hepatitis C Virus capsid assembly (360G-Wellcome-097300_Z_11_Z)

Hepatitis C Virus infection can cause chronic liver pathologies such as cirrhosis and hepatocellular carcinoma. With at least 130 million people infected world wide, the drive to understand and treat this virus is pressing. The core protein is responsible for the formation of the capsid that protects the viral genome. However very little is known about the structural information of the capsid. This project aims to elucidate the three-dimensional structure of the capsid by electron microscopy and X-ray crystallography. Further biophysical characterisation of the capsid will help to further our understanding of the molecular details of this medically relevant virus. The project then aims to discover and characterise novel inhibitors of assembly as a potential antiviral therapy.

£156,774

31 Aug 2011

Grant details
Amount Awarded 156774
Applicant Surname Caputo
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2011-08-31T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 097300/Z/11/Z
Lead Applicant Mr Alessandro Caputo
Planned Dates: End Date 2015-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof David Stuart
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