Structural investigation of the Hepatitis C Virus capsid assembly (360G-Wellcome-097300_Z_11_Z)
Hepatitis C Virus infection can cause chronic liver pathologies such as cirrhosis and hepatocellular carcinoma. With at least 130 million people infected world wide, the drive to understand and treat this virus is pressing. The core protein is responsible for the formation of the capsid that protects the viral genome. However very little is known about the structural information of the capsid. This project aims to elucidate the three- dimensional structure of the capsid by electron microscopy and X-ray crystallography. Further biophysical characterisation of the capsid will help to further our understanding of the molecular details of this medically relevant virus. The project then aims to discover and characterise novel inhibitors of assembly as a potential antiviral therapy.
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Grant Details
| Region | South East |
| Award Date | 2010-10-19T00:00:00+00:00 |
| Sponsor(s) | Prof David Stuart |
| Internal ID | 097300/Z/11/Z |
| Planned Dates: End Date | 2015-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-10-01T00:00:00+00:00 |
| Amount Awarded | 156774 |
| Financial Year | 2010/11 |
| Lead Applicant | Mr Alessandro Caputo |
| Grant Programme: Title | PhD Studentship (Basic) |
| Applicant Surname | Caputo |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | Oxford |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 156774 |