Modelling RNA regulatory networks in infectious disease (360G-Wellcome-097324_Z_11_A)
The strength and duration of the innate immune response is regulated at the post-transcriptional level by miRNAs. miR-132 has been previously shown to suppress the anti-viral response. Interestingly, a miR-132 predicted target is ARGONAUTE-2 (AGO2), a protein involved in miRNA biogenesis and function. These findings create an opportunity to investigate the interaction between miR-132 and AGO2 in the context of the innate immune response. We aim to study the effect of miR-132 on the functional activity of AGO2 in an experiment-and-modelling coupled approach by (a) measuring the abundance of relevant components of the miR- 132/AGO2 interaction system in vitro and ex vivo, and (b) building an agent-based model (ABM) of the interaction in the context of viral infection and the immune response.
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Grant Details
| Amount Awarded | 4555 |
| Applicant Surname | Leonov |
| Approval Committee | PhD Studentships |
| Award Date | 2012-12-18T00:00:00+00:00 |
| Financial Year | 2012/13 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 097324/Z/11/A |
| Lead Applicant | Mr German Leonov |
| Partnership Value | 4555 |
| Planned Dates: End Date | 2015-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Yorkshire and the Humber |
| Sponsor(s) | Prof Deborah Smith |