Investigating the epidemiology of tuberculosis and the cost effectiveness of novel diagnostic screening pathways in migrants to the UK. (360G-Wellcome-097980_Z_11_Z)
BACKGROUND: Tuberculosis is an important global public health problem and migrants to the UK have a disproportionately high burden of disease. AIM: This fellowship aims to investigate the epidemiology of tuberculosis in migrants to the UK; and examine the cost effectiveness of novel diagnostics and screening pathways for migrant tuberculosis control. OBJECTIVES: 1. Describe the epidemiology of tuberculosis in UK migrants, including: 1a. What is the prevalence of active pulmonary disea se in migrants at the time of new entrant screening? 1b. What is the future incidence in individuals without active disease on migration? 1c. What proportion of incident cases of tuberculosis are acquired in the UK? 2. Evaluate what combination of existing and novel diagnostic tests for active and latent tuberculosis would be most cost effective in UK migrants. METHODOLOGY: 1. Retrospective cohort study. Migrant screening, surveillance and strain typing databases will be probabilistic ally matched allowing the calculation of parameters in objective one. 2. A dynamic transmission model will be built to examine the combination of existing and novel diagnostic tests for active and latent tuberculosis that would be most cost effective. OPPORTUNITIES: To provide evidence for screening policy in a vulnerable population with a high burden of tuberculosis.
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Grant Details
| Amount Awarded | 181967 |
| Applicant Surname | Aldridge |
| Approval Committee | International Interview Committee |
| Award Date | 2012-03-29T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | Research Training Fellowship |
| Internal ID | 097980/Z/11/Z |
| Lead Applicant | Dr Robert Aldridge |
| Partnership Value | 181967 |
| Planned Dates: End Date | 2015-08-26T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-08-27T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Andrew Phillips |