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Sleep and Circadian Neuroscience Institute (SCNi) (360G-Wellcome-098461_Z_12_Z)

Sleep and circadian rhythm disruption (SCRD) is a clinically important feature of severe neuropsychiatric disorders, but it is rarely viewed as pathophysiologically significant, nor are its consequences appreciated or its treatment prioritised. However, emerging data challenge these assumptions, with increasing evidence that SCRD is important in illness onset, overall physical health and as a therapeutic target. Developments in circadian neuroscience now permit a meaningful scientific investigat ion of these important but neglected issues. Building upon our recent findings, and a unique breadth of expertise and shared interest, we propose to bring together molecular and systems neuroscientists, psychiatrists, psychologists, and bioengineers, to form a virtual Sleep and Circadian Neuroscience Institute (SCNi). We aim to: 1) Understand the causal relationships between SCRD and the psychoses, testing the hypothesis that pathways common to both account for the comorbidity, using preclin ical and clinical approaches. 2) Develop evidence-based interventions that correct SCRD and improve health. 3) Provide training and teaching materials in sleep/circadian neuroscience for psychiatry. 4) Disseminate research knowledge and treatment packages using web-based platforms. 5) Develop novel telemetric devices for home-based measurements of sleep and circadian physiology. SCNi will be truly multidisciplinary and translational, and will achieve these goals through five i nterlinked themes, described in Q10.

£4,434,125

17 Apr 2012

Grant details
Amount Awarded 4434125
Applicant Surname Foster
Approval Committee Strategic Awards Committee
Award Date 2012-04-17T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Strategic Award - Science
Internal ID 098461/Z/12/Z
Lead Applicant Prof Russell Foster
Other Applicant(s) Prof Paul Harrison, Prof Stuart Peirson, Prof David Bannerman, Prof Emily Holmes, Prof Guy Goodwin, Dr Gari Clifford, Dr Katharina Wulff, Prof Dame Kay Davies, Prof Daniel Freeman
Planned Dates: End Date 2018-09-30T00:00:00+00:00
Planned Dates: Start Date 2012-10-19T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
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