Development, plasticity, energy supply and pathology of myelinated axons (360G-Wellcome-099691_Z_12_Z)
The white matter of the CNS allows rapid transmission of information at low energetic cost. Despite its importance for brain function, the development, plasticity, energetics and pathology of the white matter are poorly understood. We will investigate, in vitro in brain slices and in vivo in zebrafish: (1) how electrical activity in oligodendrocyte precursors regulates myelination; (2) mechanisms underlying the tuning of conduction speed of myelinated axons; (3) mechanisms localising mitochondria in oligodendrocyte lineage cells; (4) how microglia survey the white matter in health and disease.
£162,047 25 Jun 2012