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Development, plasticity, energy supply and pathology of myelinated axons (360G-Wellcome-099691_Z_12_Z)

The white matter of the CNS allows rapid transmission of information at low energetic cost. Despite its importance for brain function, the development, plasticity, energetics and pathology of the white matter are poorly understood. We will investigate, in vitro in brain slices and in vivo in zebrafish: (1) how electrical activity in oligodendrocyte precursors regulates myelination; (2) mechanisms underlying the tuning of conduction speed of myelinated axons; (3) mechanisms localising mitochondria in oligodendrocyte lineage cells; (4) how microglia survey the white matter in health and disease.

£162,047

25 Jun 2012

Grant details
Amount Awarded 162047
Applicant Surname Krasnow
Approval Committee PhD Studentships
Award Date 2012-06-25T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 099691/Z/12/Z
Lead Applicant Ms Anna Krasnow
Planned Dates: End Date 2016-09-23T00:00:00+00:00
Planned Dates: Start Date 2012-09-24T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof David Attwell
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