Modulation of the folding energy landscape of a nascent polypeptide by interactions with the ribosome surface. (360G-Wellcome-099767_Z_12_Z)
He we propose identifying and developing a fast-folding protein domain as the new ribosome-nascent chain complex (RNC) system, and using a series of destabilising mutations to determine the effect of ribosome attachement on the foding eneregy landscape. Key goals in this project are the establishment of a suitable RNC system; development of NMR methodology for the study of surface interactions; and ultimately measurement of the effect ofribosomal attachment on the protein folding energy landscape.
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Grant Details
| Amount Awarded | 162047 |
| Applicant Surname | Paton |
| Approval Committee | PhD Studentships |
| Award Date | 2012-06-25T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 099767/Z/12/Z |
| Lead Applicant | Mr Jack Paton |
| Partnership Value | 162047 |
| Planned Dates: End Date | 2016-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Gabriel Waksman |