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Modulation of the folding energy landscape of a nascent polypeptide by interactions with the ribosome surface. (360G-Wellcome-099767_Z_12_Z)

He we propose identifying and developing a fast-folding protein domain as the new ribosome-nascent chain complex (RNC) system, and using a series of destabilising mutations to determine the effect of ribosome attachement on the foding eneregy landscape. Key goals in this project are the establishment of a suitable RNC system; development of NMR methodology for the study of surface interactions; and ultimately measurement of the effect ofribosomal attachment on the protein folding energy landscape.

£162,047

25 Jun 2012

Grant details
Amount Awarded 162047
Applicant Surname Paton
Approval Committee PhD Studentships
Award Date 2012-06-25T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 099767/Z/12/Z
Lead Applicant Mr Jack Paton
Planned Dates: End Date 2016-09-30T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Gabriel Waksman
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